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Oxford Genetics/Human Colon adenocarcinoma cell line/300302/SW-480
HumanColonadenocarcinomacellline
Passage:39
1.5Mill.cells/ml;1.5ml
ProductInfo:
HumanColonadenocarcinomacelllineSW-480
Organism:Homosapiens(human)
Ethnicity:Caucasian
Age:51yearsold
Gender:Male
Tissue:Colon,GradeIV,Dukes"typeB
Morphology:Epithelial
Celltype:Adenocarcinoma,colorectal
GrowthProperties:Monolayer,adherent
Description:TheSW480celllineoriginatedfromasurgicalspecimenofaprimarytumorofamoderatelydifferentiatedcolonadenocarcinoma.ThelineisnegativeforCSAp(CSAp-)andcolonantigen3.Thecellsarepositiveforkeratinbyimmunoperoxidasestaining.ThereisaG->Amutationincodon273ofthep53generesultinginanArg->HissubstitutionandaC->Tmutationincodon309resultinginaPro->Sersubstitution.Thecellsexpresselevatedlevelsofp53protein.Thelineispositiveforexpressionofc-myc,K-ras,H-ras,N-ras,myb,sisandfosoncogenes.N-myconcogeneexpressionwasnotdetected.Matrilysin,ametalloproteinaseassociatedwithtumorinvasiveness,isnotexpressed.ThecellshavebeenreportedtoproduceGM-CSF.Thislinehasamutationincodon12oftherasprotooncogene,andcanbeusedasapositivecontrolforPCRassaysofmutationinthiscodon.
More:
ProductName:SW-480
ProductCode:300302
Size:cryovial
StoreTemperature:-196°C
ShipTemperature:-70°C
UNSPSCCode:41106514
